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周乐
性      别： 男 职      称： 教育,高等学校教师,教授
籍      贯： 陕西省 咸阳市 现 居 地： 陕西省 渭南市
毕业院校： 西北农林科技大学 专      业： 动物医学
出生年月： 1965年 工作单位： 西北农林科技大学理学院
邮       箱： betterzl@163.com 联系电话：
学       历： 博士

【人物简介】

　　周乐，男，1965年出生于陕西蒲城县， 现为西北农林科技大学理学院有机化学专业教授。教育部高等学校化学与化工学科教学指导委员会会员。教育部第三届霍英东基金优秀教师奖获得者。 　　工作学习简历 　　2010.12-今 教授， 西北农林科技大学理学院 　　2005.12-2007.1 访问学者，美国宾夕法尼亚洲立大学化学系 　　1996.7-2001.12 副教授， 西北农林科技大学（原西北农业大学）基础科学系 　　1999.9-2005.1 副主任，西北农林科技大学测试中心 　　1994.9-1998.7 博士，西北农林科技大学（原西北农业大学）动物医学系 　　1994.12-1996.7 讲师，西北农林科技大学（原西北农业大学）基础科学系 　　1990.12-1994.12,助教，西北农林科技大学（原西北农业大学）基础科学系 　　1987.9-1990.12 硕士，西北农林科技大学（原西北农业大学）基础科学系 　　1983.9-1987.6 学士，西北大学化学系

【研究方向】

主要从事有机合成、天然产物化学和药物化学的研究。近年来的研究重点是天然活性化合物的构效关系、天然活性化合物类似物的分子设计、合成及其药理活性、植物化学成分及其药理活性成分和有机不对称氢化反应。在药物研发方面，着重于动物、植物和人的抗菌药物、抗病毒药物、抗癌药物和抗虫药物。

【研究成果】

【科研项目】

【论文著作】

　　已发表学术论文95篇，其中sci收录22篇，申报国家发明专利3项，主编（参编）专著6部。近年来发表的主要论文： 　　1. jian yang, yan-hong zhang, fang miao, le zhou, wei sun. two new bufadienolides from the rhizomes of helleborus thibetanus franch. fitoterapia, 2010, 81. http://dx.doi.org/10.1016/j.fitote.2010.03.009. 　　2. fang miao, bao-fu qin, li-zhen yang, xin-juan yang and le zhou. （e）-3-[2,5-dioxo-3-（propan-2-ylidene）pyrrolidin-1-yl]acrylic acid, acta crystallographica section e, structure reports online, 2010, e66, o634. 　　3. fang miao, xin-juan yang, le zhou, hai-jun hu, feng zheng, xu-dong ding, dong-mei sun, chun-dong zhou, wei sun. structural modification of sanguinarine and chelerythrine and their antibacterial activity, natural product research, 2010, 24. 　　4. yang xin-juan, zhou le, miao fang, wang xin, sun wei, geng hui-ling. isolation and identification of alkaloids from macleaya microcarpa（maxim） fedde, acta bot. boreal.–occident. sin., 2009, 30（2）： 0405-0411. 　　5. xianfeng sun, wei li, guohua hou, le zhou, and xumu zhang. axial chirality control by 2,4-pentanediol for the alternative synthesis of c3-tunephos chiral diphosphine ligands and their applications in highly enantioselective ruthenium-catalyzed hydrogenation of β-keto esters, adv. synth. catal. 2009, 351, 2553-2557. doi: 10.1002/adsc.200900589 　　6. sun xianfeng, li wei, zhou le, zhang xumu. matching and mismatching effects of hybrid chiral biaxial bisphosphine ligands in enantioselective hydrogenation of ketoesters. chemistry--a european journal, 2009, 15（30）： 7302-7305. 　　7. geng huiling, zhang weicheng, chen jian, hou guohua, zhou le, zou yaping, wu wenjun, zhang xumu. rhodium-catalyzed enantioselective and diastereoselective hydrogenation of β-ketoenamides: efficient access to anti 1,3-amino alcohols. angewandte chemie, international edition, 2009, 48（33）： 6052-6054. 　　8. le zhou, chao lv, gai-ling wang, hui-ling geng, jian-wu yang, peng chen. syntheses of r-β-rutinosides by rutin-degrading reaction, journal of asian natural product research, 2009, 11（1）： 18-23. 　　9. li, wei; sun, xianfeng; zhou, le; hou, guohua; yu, shichao; zhang, xumu. highly efficient and highly enantioselective asymmetric hydrogenation of ketones with tunesphos / 1,2-diamine-ruthenium（ii） complexes. j. org. chem., 2009, 74 （3）： 1397-1399. 　　10. le zhou, xin-ke li, fang miao, ming-li yang, xin-juan yang, wei sun, jian yang. further studies on the chemical constituents of chinese folk medicine gentiana apiata n.e.br., journal of asian natural product research, 2009,11（4）： 345-351. 　　11. ma, yanni, zhou le, deng dongsheng, ji baoming. 4,4',6,6'-tetramethyl-2,2'-bipyrimidine hexahydrate. acta crystallographica, section e: structure reports online, 2009, e65（4）， o848-o849. 　　12sun x f, zhou l, li w, zhang x m. convenient divergent strategy for the synthesis of tunephos-type chiral diphosphine ligands and their applications in highly enantioselective ru-catalyzed hydrogenations. journal of organic chemistry, 2008, 73（3）： 1143-1146. 　　13. hu x y, luo y g, chen x z, zhou l , zhang g l. chemical constituents of nouelia insignis franch, journal of asian natural product research, 2008, 10（2）： 125-131. （if 0.651） 　　14. hong-ji ma, chen xu, zhi-qiang wang, le zhou* and bao-ming ji. 2,4,6-trimethyl-1,3,5-tris （morpholinomethyl） benzene, acta cryst. 2008, e64, o993 （if 0.367） 　　15. sun x f, zhou l, zhang x m. rh-catalyzed highly enantioselective synthesis of β-methylcinnamic acids, angewandte chemie international edition, 2007, 46（15）： 2623-2626. 　　16. hu x y, wu x w, mei n, zhou l*. structure characteristics of a sesquiterpene lactone from nouelia insignis franch by 2d nmr, chinese journal of magnetic resonance, 2007, 24（2）： 141-145. 　　17. 周乐， 王宁， 苗芳， 赵海双， 田鹏。 秦岭龙胆的化学成分。 有机化学， 2004, 24（10）： 1249-1252.

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(these only cover the last step of the expression; to cover the whole expression, use parenthesis: (myoptionalvar.foo)!mydefault, (myoptionalvar.foo)?? ---- ---- ftl stack trace ("~" means nesting-related): - failed at: ${c.admheadship} [in template "web-inf/t/cms/www/xatrm/techexpert/detail.html" at line 174, column 45] ---- java stack trace (for programmers): ---- freemarker.core.invalidreferenceexception: [... exception message was already printed; see it above ...] at freemarker.core.invalidreferenceexception.getinstance(invalidreferenceexception.java:134) at freemarker.core.evalutil.coercemodeltotextualcommon(evalutil.java:451) at freemarker.core.evalutil.coercemodeltostringormarkup(evalutil.java:374) at freemarker.core.dollarvariable.calculateinterpolatedstringormarkup(dollarvariable.java:96) at freemarker.core.dollarvariable.accept(dollarvariable.java:59) at freemarker.core.environment.visit(environment.java:362) at freemarker.core.iteratorblock$iterationcontext.executenestedcontent(iteratorblock.java:263) at freemarker.core.iteratorblock$iterationcontext.accept(iteratorblock.java:200) at freemarker.core.environment.visititeratorblock(environment.java:595) at freemarker.core.iteratorblock.acceptwithresult(iteratorblock.java:81) at freemarker.core.iteratorblock.accept(iteratorblock.java:67) at freemarker.core.environment.visit(environment.java:326) at freemarker.core.environment.visit(environment.java:332) at freemarker.core.environment.process(environment.java:305) at freemarker.template.template.process(template.java:384) at com.xatrm.common.web.springmvc.simplefreemarkerview.rendermergedtemplatemodel(simplefreemarkerview.java:114) at org.springframework.web.servlet.view.abstracttemplateview.rendermergedoutputmodel(abstracttemplateview.java:167) at org.springframework.web.servlet.view.abstractview.render(abstractview.java:303) at org.springframework.web.servlet.dispatcherservlet.render(dispatcherservlet.java:1257) at org.springframework.web.servlet.dispatcherservlet.processdispatchresult(dispatcherservlet.java:1037) at org.springframework.web.servlet.dispatcherservlet.dodispatch(dispatcherservlet.java:980) at org.springframework.web.servlet.dispatcherservlet.doservice(dispatcherservlet.java:897) at org.springframework.web.servlet.frameworkservlet.processrequest(frameworkservlet.java:970) at org.springframework.web.servlet.frameworkservlet.doget(frameworkservlet.java:861) at javax.servlet.http.httpservlet.service(httpservlet.java:622) at org.springframework.web.servlet.frameworkservlet.service(frameworkservlet.java:846) at javax.servlet.http.httpservlet.service(httpservlet.java:729) at org.apache.catalina.core.applicationfilterchain.internaldofilter(applicationfilterchain.java:230) at org.apache.catalina.core.applicationfilterchain.dofilter(applicationfilterchain.java:165) at org.apache.tomcat.websocket.server.wsfilter.dofilter(wsfilter.java:52) at org.apache.catalina.core.applicationfilterchain.internaldofilter(applicationfilterchain.java:192) at org.apache.catalina.core.applicationfilterchain.dofilter(applicationfilterchain.java:165) at org.jasig.cas.client.session.singlesignoutfilter.dofilter(singlesignoutfilter.java:76) at org.apache.catalina.core.applicationfilterchain.internaldofilter(applicationfilterchain.java:192) at org.apache.catalina.core.applicationfilterchain.dofilter(applicationfilterchain.java:165) at ci.filter.sqlinjectfilter.dofilter(sqlinjectfilter.java:157) at org.apache.catalina.core.applicationfilterchain.internaldofilter(applicationfilterchain.java:192) at org.apache.catalina.core.applicationfilterchain.dofilter(applicationfilterchain.java:165) at ci.filter.xssfilter.dofilter(xssfilter.java:96) at org.apache.catalina.core.applicationfilterchain.internaldofilter(applicationfilterchain.java:192) at org.apache.catalina.core.applicationfilterchain.dofilter(applicationfilterchain.java:165) at ci.filter.securityfilter.dofilter(securityfilter.java:25) at org.apache.catalina.core.applicationfilterchain.internaldofilter(applicationfilterchain.java:192) at org.apache.catalina.core.applicationfilterchain.dofilter(applicationfilterchain.java:165) at com.xatrm.common.web.xssfilter.dofilter(xssfilter.java:40) at org.apache.catalina.core.applicationfilterchain.internaldofilter(applicationfilterchain.java:192) at org.apache.catalina.core.applicationfilterchain.dofilter(applicationfilterchain.java:165) at org.apache.shiro.web.servlet.abstractshirofilter.executechain(abstractshirofilter.java:449) at org.apache.shiro.web.servlet.abstractshirofilter$1.call(abstractshirofilter.java:365) at org.apache.shiro.subject.support.subjectcallable.docall(subjectcallable.java:90) at org.apache.shiro.subject.support.subjectcallable.call(subjectcallable.java:83) at org.apache.shiro.subject.support.delegatingsubject.execute(delegatingsubject.java:383) at org.apache.shiro.web.servlet.abstractshirofilter.dofilterinternal(abstractshirofilter.java:362) at org.apache.shiro.web.servlet.onceperrequestfilter.dofilter(onceperrequestfilter.java:125) at org.springframework.web.filter.delegatingfilterproxy.invokedelegate(delegatingfilterproxy.java:346) at org.springframework.web.filter.delegatingfilterproxy.dofilter(delegatingfilterproxy.java:262) at org.apache.catalina.core.applicationfilterchain.internaldofilter(applicationfilterchain.java:192) at org.apache.catalina.core.applicationfilterchain.dofilter(applicationfilterchain.java:165) at org.springframework.orm.hibernate4.support.opensessioninviewfilter.dofilterinternal(opensessioninviewfilter.java:151) at org.springframework.web.filter.onceperrequestfilter.dofilter(onceperrequestfilter.java:107) at org.apache.catalina.core.applicationfilterchain.internaldofilter(applicationfilterchain.java:192) at org.apache.catalina.core.applicationfilterchain.dofilter(applicationfilterchain.java:165) at org.springframework.web.filter.characterencodingfilter.dofilterinternal(characterencodingfilter.java:197) at org.springframework.web.filter.onceperrequestfilter.dofilter(onceperrequestfilter.java:107) at org.apache.catalina.core.applicationfilterchain.internaldofilter(applicationfilterchain.java:192) at org.apache.catalina.core.applicationfilterchain.dofilter(applicationfilterchain.java:165) at com.xatrm.common.web.processtimefilter.dofilter(processtimefilter.java:35) at org.apache.catalina.core.applicationfilterchain.internaldofilter(applicationfilterchain.java:192) at org.apache.catalina.core.applicationfilterchain.dofilter(applicationfilterchain.java:165) at org.apache.catalina.core.standardwrappervalve.invoke(standardwrappervalve.java:198) at org.apache.catalina.core.standardcontextvalve.invoke(standardcontextvalve.java:108) at 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java.util.concurrent.threadpoolexecutor.runworker(threadpoolexecutor.java:1142) at java.util.concurrent.threadpoolexecutor$worker.run(threadpoolexecutor.java:617) at org.apache.tomcat.util.threads.taskthread$wrappingrunnable.run(taskthread.java:61) at java.lang.thread.run(thread.java:745)
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